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Histiocytosis X

Langerhans cell histiocytosis has a wide spectrum of clinical manifestations, acute or chronic, disseminated or localized. Some lesions regress spontaneously and other herald the development of a life-threating disorder. This group of disorders of histiocyte proliferation includes LETTERER-SIWE DISEASE ( acute and disseminated form), HAND-SCHULLER-CHRISTIAN SYNDROME (subacute form), and EOSINOPHILIC GRANULOMA (solitary eosinophilic granuloma of bone). Langerhans cell histiocytosis is characterized by the presence of many Langerhans cells (skin histiocytes with a specific antigen-presenting function) in the lesional tissues.

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