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Congenital Toxoplasmosis


Congenital infection with the protozoan Toxoplasma gondii occurs when the mother acquires toxoplasmosis during pregnancy by either eating inadequately cooked meat or following contact with soil containing oocysts from the excreta of infected animals. The classic clinical findings are chorioretinitis, hydrocephalus, convulsions, and intracerebral calcifications. Generalized disease can also cause prematurity, cataracts, optic atrophy, hepatosplenomegaly, lymphadenopathy, vomiting, diarrhoea, and rash. Cutaneous lesions are frequently maculopapular or punctate, although petechiae, ecchymoses, calcifications and ’blueberry muffin’ lesions (areas of extramedullary hematopoiesis) may occur. The likelihood of foetal infection is greatest if maternal infection occurs during the third trimester.




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