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Leprechaunism Syndrome

Rare and poorly defined syndrome that seems to be inherited. It is characterized by intra-uterine and postnatal growth retardation, decreased subcutaneous tissue and muscle mass, a characteristic facies, and tissue resistance to insulin. The neonate shows a broad nose, low set ears and hypertrichosis of the forehead and cheeks. The thickened skin appears too large for the body and is folded at the flexures. Muscle wasting is usually present and often progressive. Early death is usual.

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