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Hyperpigmentation Due to Heavy Metals

Systemic absorption of chemicals may cause discolouration of the skin. Deposition of silver within the dermis produces a bluish-grey or slate-coloured discolouration of the skin called argyria. The administration of gold salts followed by exposure to ultraviolet light may cause a bluish-grey or purplish pigmentation which is more prominent around the eyes and limited to areas of sun exposure. It is called chrysiasis. Deposition of mercury within the dermis results in a slate-grey pigmentation in areas of topical application.

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