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Drug-Induced Hyperpigmentation

A variety of drugs may induce pigmentation. Chlorpromazine and related phenothiazines may induce a bluish-grey pigmentation of the sun-exposed areas of the skin in patients receiving high doses for long periods. Hydantoin may cause pigmentation of the face and neck resembling chloasma. Prolonged intake of inorganic arsenic may result in diffuse pigmentation, most intense on the trunk. Antimalarial drugs may induce a bluish-grey pigmentation on the face, neck, lower legs and forearms which may develop into a blue-black colour.

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