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Down´s Syndrome

A chromosome disorder characterized by a small, anteroposteriorly flattened skull, short, flat-bridge nose, epicanthal fold, short phalanges, widened spaces between the first and second digits of hands and feet, and moderate to severe mental retardation, with ALZHEIMER’S DISEASE developing in the fourth or fifth decade. The chromosomal abnormality is trisomy of chromosome 21 associated with late maternal age. Down syndrome is also called trisomy 21 and nondisjunction. This disease was formerly called mongolism. (Dorland, 27th ed)

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